Name: Hot sale with fast delivery154361-50-9 Capecitabine good supplier
SKU: 154361-50-9
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Afine Chemicals Limited

Country: China (Mainland)

Business Type:Lab/Research institutions

: Mr.Wei Fei

Tel: +86-571-85134551

Mobile:

Tel: +86-571-85134551

Fax: +86-571-85134895

URL: http://www.afinechem.com

Province/state: zhejiang

City: Hangzhou

Street: No. 206 Zhen Hua Road, Hangzhou 310030, Zhejiang, China

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Hot sale with fast delivery154361-50-9 Capecitabine good supplier

CAS NO.154361-50-9

Min.Order: 100 Gram
Payment Terms: L/C,D/P,T/T,

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Capecitabine good supplier
154361-50-9 with fast delivery
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ProName: Hot sale with fast delivery154361-50-9...
CasNo: 154361-50-9
Molecular Formula: C15H22FN3O6
Appearance: white powder
Application: pharmaceutical active ingredient
DeliveryTime: one week
PackAge: 0.1~1kg/foil bag; 1kg/tin ; 25kg/drum ...
Port: shanghai , hangzhou etc
ProductionCapacity: 1000 Kilogram/Week
Purity: 99%
Storage: store in cool, dry, ventilated place
Transportation: by air;by sea; by express；Normal Good
LimitNum: 100 Gram
Related Substances: Effective ingredients >99%
Residue on Ignition: 0.1
Heavy Metal: 0
Valid Period: 3 year
COA&Document: Please send us inquiry

Superiority

Hot sale with fast delivery154361-50-9 Capecitabine good supplier、

Product Name: Capecitabine

Synonyms: Capcitabine;Pentyl (1-((2R,3R,4S,5R)-3,4-dihydroxy-5-methyltetrahydrofuran-2-yl)-5-fluoro-2-oxo-1,2-dihydr;5'-DEOXY-5-FLUOROCYTISINE;5'-DEOXY-5-FLUORO-N-[(PENTYLOXY)CARBONYL]CYTIDINE;CAPECITABINE;RO-9-1978;pentyl [1-(3,4-dihydroxy-5-methyl-oxolan-2-yl)-5-fluoro-2-oxo-pyrimidin-4-yl]aminoformate;XELODA

CAS: 154361-50-9

MF: C15H22FN3O6

MW: 359.35

EINECS: 604-948-1

Capecitabine Usage And Synthesis

Indications and Uses Capecitabine is a new form of oral fluorinated pyrimidine drug. Capecitabine was developed by Roche Pharmaceuticals, and its commercial name is Xeloda. Capecitabine can change in vivo into 5- FU, an anti-metabolizim fluorine pyrimidine deoxynucleoside carbamate drug that targets cancer cells to inhibit cell division and disrupt RNA and protein synthesis. Its effects are significantly tied to the level of TP enzyme expression in neoplastic tissue and to DPD enzyme in vivo expression. It is suitable as further treatment for advanced primary or metastatic breast cancer patients who have not responded to paclitaxel or anthracycline antibiotics. As an anticancer drug, it is mostly used to treat advanced primary or metastatic breast cancer, as well as in treatment for non-small cell lung cancer, pancreatic cancer, bladder cancer, rectal cancer, colon cancer, gastric cancer, and other solid tumors. Many drugs such as taxanes (paclitaxel, docetaxel, mitomycin, cisplatin, etc.) can increase TP enzyme expression in neoplastic tissues and also have curative effects on gastric cancer. When used in combination with Capecitabine, these drugs can also improve Capecitabine’s anticancer abilities and produce synergistic effects.

Clinical trials Analyses of nearly 400 randomized comparisons of clinical outcomes show that a combination of adriamycin, cisplatin or oxaliplatin with 5-FU, compared to a combination of these drugs with Capecitabine, has a two-fold difference in curative efficacy and lowers toxicty. A large-scale Chinese clinical trial of Capecitabine in combination with DDP in the treatment of stage II gastric cancer also proves its advantages of high efficacy, low toxicity, and affordability.

Drug interactions Currently, there are no side effects of clinical significance when used in combination with antihistamines, NSAIDs, morphine, paracetamol, aspirin, antiemetic drugs, and H2 receptor antagonist drugs.

Capecitabine’s binding rate with serum protein is relatively low (64%), and its possibility of interacting through substitution with drugs that bind closely with proteins is currently unknown. In external experiments, Capecitabine has not shown any influence on human liver microsomal P450 enzyme.

If any phenytoin and coumarin derivatives anticoagulants are used in combination with Capecitabine, dosages should be lowered.

2. Specialized in the fine chemicals and pharmaceuticals1. "Top 100 innovation-oriented export enterprises Of Hangzhou" honored by Hangzhou government

3. A leading manufacturer and trader of APIs in China

Top 100 export enterprises of Hangzhou

Details

Company Introduction

AFINE CHEMICALS LIMITED is specialized in the fine chemicals and pharmaceuticals and we have enjoyed great popularity in world markets. Since 2005, we have been rapidly growing to a leading manufacturer and trader of APIs in China.

Now we own two independent business divisions: Fine chemicals division and Pharmaceutical division:

(1). Fine chemical department: manufacturing and trading a variety of high-quality of optical brightener and textile auxiliary as well as Dye stuff, Pigments and other fine chemicals. Now we are one of the leading exporters of Optical Brightener in China.

(2). Pharmaceutical division: manufacturing, contract R&D, marketing and distribution of pharmaceutical active ingredients, intermediates and feed additives

Innovation and good service are the secrets of our success and rapid growth. Continuous innovation improves the quality of our products, and helps us launch new market-oriented products into the market. Warm and efficient service guarantees the timely, professional and sincere service to our clients.

We are awarded the title of "Top 100 innovation-oriented export enterprises Of Hangzhou in 2008" by Hangzhou government among more than 13,000 competitors in March 2009. and we are doing our best to manage the best product and the most reasonable price. Looking forward to establish businessship with you!

1. Established in 2005, with two independent business divisions: Fine chemicals division; Pharmaceutical division.

a. "Top 100 innovation-oriented export enterprises Of Hangzhou" honored by Hangzhou government

b. Specialized in the fine chemicals and pharmaceuticals

c. A leading manufacturer and trader of APIs in China

2. Main product:(Pharmaceutical division)

· Pharmaceutical active ingredients

· Pharmaceutical intermediates

· custom synthesis